Early auditory responses to speech sounds in Parkinson’s disease: preliminary data

Mollaei, F. ORCID: https://orcid.org/0000-0003-2916-9750, Shiller, D. M., Baum, S. R. and Gracco, V. L. (2022) Early auditory responses to speech sounds in Parkinson’s disease: preliminary data. Scientific Reports, 12. 1019. ISSN 2045-2322 doi: 10.1038/s41598-022-05128-8

Abstract/Summary

Parkinson’s disease (PD), as a manifestation of basal ganglia dysfunction, is associated with a number of speech defcits, including reduced voice modulation and vocal output. Interestingly, previous work has shown that participants with PD show an increased feedback-driven motor response to unexpected fundamental frequency perturbations during speech production, and a heightened ability to detect diferences in vocal pitch relative to control participants. Here, we explored one possible contributor to these enhanced responses. We recorded the frequency-following auditory brainstem response (FFR) to repetitions of the speech syllable [da] in PD and control participants. Participants with PD displayed a larger amplitude FFR related to the fundamental frequency of speech stimuli relative to the control group. The current preliminary results suggest the dysfunction of the basal ganglia in PD contributes to the early stage of auditory processing and may refect one component of a broader sensorimotor processing impairment associated with the disease.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/102512
Identification Number/DOI	10.1038/s41598-022-05128-8
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience Life Sciences > School of Psychology and Clinical Language Sciences > Department of Clinical Language Sciences
Publisher	Nature Publishing Group
Download/View statistics	View download statistics for this item