Hybrid nanoparticles for haloperidol encapsulation: quid est optimum?

Filippov, S. K., Khusnutdinov, R. R., Inham, W., Liu, C., Nikitin, D. O., Semina, I. I., Garvey, C. J., Nasibullin, S. F., Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630, Zhang, H. and Moustafine, R. I. (2021) Hybrid nanoparticles for haloperidol encapsulation: quid est optimum? Polymers, 13 (23). 4189. ISSN 2073-4360 doi: 10.3390/polym13234189

Abstract/Summary

The choice of drug delivery carrier is of paramount importance for the fate of a drug in a human body. In this study, we have prepared the hybrid nanoparticles composed of FDA-approved Eudragit L100-55 copolymer and polymeric surfactant Brij98 to load haloperidol—an antipsychotic hydrophobic drug used to treat schizophrenia and many other disorders. This platform shows good drug-loading efficiency and stability in comparison to the widely applied platforms of mesoporous silica (MSN) and a metal–organic framework (MOF). ZIF8, a biocompatible MOF, failed to encapsulate haloperidol, whereas MSN only showed limited encapsulation ability. Isothermal titration calorimetry showed that haloperidol has low binding with the surface of ZIF8 and MSN in comparison to Eudragit L100-55/Brij98, thus elucidating the striking difference in haloperidol loading. With further optimization, the haloperidol loading efficiency could reach up to 40% in the hybrid Eudragit L100-55/Brij98 nanoparticles with high stability over several months. Differential scanning calorimetry studies indicate that the encapsulated haloperidol stays in an amorphous state inside the Eudragit L100-55/Brij98 nanoparticles. Using a catalepsy and open field animal tests, we proved the prolongation of haloperidol release in vivo, resulting in later onset of action compared to the free drug.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/101696
Identification Number/DOI	10.3390/polym13234189
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	MDPI
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