A nutrigenetic update on CETP gene - diet interactions on lipid-related outcomes

Wuni, R., Kuhnle, G. G. C. ORCID: https://orcid.org/0000-0002-8081-8931, Azzari Wynn-Jones, A. and Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930 (2022) A nutrigenetic update on CETP gene - diet interactions on lipid-related outcomes. Current Atherosclerosis Reports, 24. pp. 119-132. ISSN 1534-6242 doi: 10.1007/s11883-022-00987-y

Abstract/Summary

Purpose of Review An abnormal lipid profile is considered a main risk factor for cardiovascular diseases and evidence suggests that single nucleotide polymorphisms (SNPs) in the cholesteryl ester transfer protein (CETP) gene contribute to variations in lipid levels in response to dietary intake. The objective of this review was to identify and discuss nutrigenetic studies assessing the interactions between CETP SNPs and dietary factors on blood lipids. Recent Findings Relevant articles were obtained through a literature search of PubMed and Google Scholar through to July 2021. An article was included if it examined an interaction between CETP SNPs and dietary factors on blood lipids. From 49 eligible nutrigenetic studies, 27 studies reported significant interactions between 8 CETP SNPs and 17 dietary factors on blood lipids in 18 ethnicities. The discrepancies in the study findings could be attributed to genetic heterogeneity, and differences in sample size, study design, lifestyle and measurement of dietary intake. The most extensively studied ethnicities were those of Caucasian populations and majority of the studies reported an interaction with dietary fat intake. The rs708272 (TaqIB) was the most widely studied CETP SNP, where ‘B1’ allele was associated with higher CETP activity, resulting in lower high-density lipoprotein cholesterol and higher serum triglycerides under the influence of high dietary fat intake. Summary Overall, the findings suggest that CETP SNPs might alter blood lipid profiles by modifying responses to diet, but further large studies in multiple ethnic groups are warranted to identify individuals at risk of adverse lipid response to diet.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/101100
Identification Number/DOI	10.1007/s11883-022-00987-y
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Institute for Food, Nutrition and Health (IFNH) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Publisher	Springer
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