A standardised BCR resistance test for all anticoagulant rodenticides

Prescott, C. V., Buckle, A. P., Hussain, I. and Endepols, S. (2007) A standardised BCR resistance test for all anticoagulant rodenticides. International Journal of Pest Management, 53 (4). pp. 265-272. ISSN 0967-0874 doi: 10.1080/09670870701245249

Abstract/Summary

This paper presents a reappraisal of the blood clotting response (BCR) tests for anticoagulant rodenticides, and proposes a standardised methodology for identifying and quantifying physiological resistance in populations of rodent species. The standardisation is based on the International Normalised Ratio, which is standardised against a WHO international reference preparation of thromboplastin, and allows comparison of data obtained using different thromboplastin reagents. ne methodology is statistically sound, being based on the 50% response, and has been validated against the Norway rat (Rattus norvegicus) and the house mouse (Mus domesticus). Susceptibility baseline data are presented for warfarin, diphacinone, chlorophacinone and coumatetralyl against the Norway rat, and for bromadiolone, difenacoum, difethialone, flocoumafen and brodifacoum against the Norway rat and the house mouse. A 'test dose' of twice the ED50 can be used for initial identification of resistance, and will provide a similar level of information to previously published methods. Higher multiples of the ED50 can be used to assess the resistance factor, and to predict the likely impact on field control.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/10071
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences
Uncontrolled Keywords	anticoagulant resistance, blood clotting response test, Rattus, norvegicus, Mus domesticus, anticoagulant rodenticides, resistance ratio, CLOTTING RESPONSE TEST, RATTUS-NORVEGICUS, NORWAY RATS, WARFARIN-RESISTANCE
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